| Autor: |
Chun-Yan Guan, Tian-Jiao Han, Shi-Kun Jia, Yuan-Zhao Hua, Guang-Jian Mei |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
Green Synthesis and Catalysis, Vol 4, Iss 3, Pp 258-262 (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2666-5549 |
| DOI: |
10.1016/j.gresc.2022.05.003 |
| Popis: |
The first diastereodivergent formal [4 + 1] cycloaddition reactions of azoalkenes with p-quinone methides (p-QMs) have been accomplished. The reported reaction occurred via a domino oxa-1,4-addition/1,6-addition process, allowing the use of common azoalkenes as C1 synthons. A broad range of 2,3-dihydrobenzofurans was smoothly prepared in good yields and with reversible diastereoselectivities. The steric hindrance and hydrogen-bonding interaction were proposed to account for the two different modes of diastereo-control. The projected reaction features the employment of azoalkene as carbene-like C1 synthon, mild conditions, broad substrate scope and tunable diastereoselectivity. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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