| Autor: |
Wadah Osman, Mona S Mohammed, Hassan S Khalid, Abdelkhalig Muddathir, Shaza W. Shantier, Bashier Osman, Iman Abdoon |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
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| Zdroj: |
Advances in Pharmacological and Pharmaceutical Sciences, Vol 2020 (2020) |
| Druh dokumentu: |
article |
| ISSN: |
2633-4690 |
| DOI: |
10.1155/2020/3201463 |
| Popis: |
Diabetes is one of the world’s major health problems, and many reports have supported the role of oxidative stress in the pathogenesis of both type 1 and type 2 diabetes. The present study aims to evaluate the antidiabetic and antioxidant activity of Bauhinia rufescens, a plant used in Sudanese folkloric medicine for the treatment of diabetes. It was also aimed to identify isolates and characterize the bioactive antidiabetic and antioxidant compounds using bioactivity-guided fractionation followed by high-performance thin-layer chromatography (HPTLC) autobiography, liquid chromatography-mass spectrometric analysis, and nuclear magnetic resonance (NMR). Two potential compounds were successfully isolated and identified which may provide new leads for more potent analogues in drug discovery. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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