Cerebrospinal fluid and plasma neurofilament light relate to abnormal cognition

Autor: Katie E. Osborn, Omair A. Khan, Hailey A. Kresge, Corey W. Bown, Dandan Liu, Elizabeth E. Moore, Katherine A. Gifford, Lealani Mae Y. Acosta, Susan P. Bell, Timothy J. Hohman, Kaj Blennow, Henrik Zetterberg, Angela L. Jefferson
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 11, Iss 1, Pp 700-709 (2019)
Druh dokumentu: article
ISSN: 2352-8729
DOI: 10.1016/j.dadm.2019.08.008
Popis: Abstract Introduction Neuroaxonal damage may contribute to cognitive changes preceding clinical dementia. Accessible biomarkers are critical for detecting such damage. Methods Plasma and cerebrospinal fluid (CSF) neurofilament light (NFL) were related to neuropsychological performance among Vanderbilt Memory & Aging Project participants (plasma n = 333, 73 ± 7 years; CSF n = 149, 72 ± 6 years) ranging from normal cognition (NC) to mild cognitive impairment (MCI). Models adjusted for age, sex, race/ethnicity, education, apolipoprotein E ε4 carriership, and Framingham Stroke Risk Profile. Results Plasma NFL was related to all domains (P values ≤ .008) except processing speed (P values ≥ .09). CSF NFL was related to memory and language (P values ≤ .04). Interactions with cognitive diagnosis revealed widespread plasma associations, particularly in MCI participants, which were further supported in head‐to‐head comparison models. Discussion Plasma and CSF NFL (reflecting neuroaxonal injury) relate to cognition among non‐demented older adults albeit with small to medium effects. Plasma NFL shows particular promise as an accessible biomarker with relevance to cognition in MCI.
Databáze: Directory of Open Access Journals