Relationships of interleukin-10 with the regulatory T cell ratio and prognosis of cervical cancer patients

Autor: Beibei Wang, Haoyu Wang, Peiquan Li, Liangliang Wang, Hongli Liu, Jingbo Liu, Lihua Wang
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Zdroj: Clinics, Vol 73, Iss 0 (2018)
Druh dokumentu: article
ISSN: 1980-5322
DOI: 10.6061/clinics/2018/e679
Popis: OBJECTIVE: This study investigated serum interleukin-10 (IL-10) levels, changes in peripheral blood CD4+CD25+ regulatory T cell (PBCDT) ratios, and the prognosis of cervical cancer (CC) patients. METHODS: Seventy patients with CC composed the observation group, and 70 healthy subjects composed the control group. The PBCDT ratios in the CC patients and healthy subjects were calculated. Serum IL-10 levels were detected with a double antibody sandwich enzyme-linked immunosorbent assay (ELISA). RESULTS: The PBCDT ratio was higher in the patients with active CC [12.16±2.41%] than in the control subjects [6.34±1.05%]. Serum IL-10 levels were higher in the patients with CC [384±106 pg/ml] than in the control subjects [104±50 pg/ml]; the differences in both PBCDT ratio and IL-10 level were statistically significant (p
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