Anti-carbamylated protein antibody isotype pattern differs between palindromic rheumatism and rheumatoid arthritis
| Autor: | Raul Castellanos-Moreira, Sebastian C. Rodriguez-Garcia, Sonia Cabrera-Villalba, María José Gomara, Georgina Salvador, Virginia Ruiz-Esquide, Julio Ramirez, Jose Inciarte-Mundo, Rosa Morla, Cristina Garcia-Moreno, Andrea Cuervo, Jose A. Gómez-Puerta, Juan D. Cañete, Isabel Haro, Raimon Sanmarti |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: | |
| Zdroj: | Therapeutic Advances in Musculoskeletal Disease, Vol 12 (2020) |
| Druh dokumentu: | article |
| ISSN: | 1759-7218 1759720X |
| DOI: | 10.1177/1759720X20978139 |
| Popis: | Background: A restricted response against citrullinated peptides/proteins, with less isotype usage, has been found in palindromic rheumatism (PR) in comparison with rheumatoid arthritis (RA). We hypothesized that this different antibody response may be observed for other post-translational modified proteins. We compared the prevalence and isotype usage of two specificities of anti-carbamylated peptide/protein antibodies (Anti-CarP) in patients with PR and RA. Methods: Cross-sectional study including 54 patients with pure PR and 53 patients with RA, matched by sex, age, disease duration and ACPA. Anti-CarP specificities were determined by home-made enzyme-linked immunosorbent assay tests using a synthetic chimeric fibrin/filaggrin homocitrullinated peptide (CFFHP) and fetal calf serum (FCS) homocitrullinated protein as antigens. IgG, IgA and IgM isotypes were measured. Results: Anti-CarP were positive (CFFHP or FCS) in 24% and 64% of patients with PR and RA, respectively ( p |
| Databáze: | Directory of Open Access Journals |
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