| Autor: |
Ines Foessl, J. H. Duncan Bassett, Åshild Bjørnerem, Björn Busse, Ângelo Calado, Pascale Chavassieux, Maria Christou, Eleni Douni, Imke A. K. Fiedler, João Eurico Fonseca, Eva Hassler, Wolfgang Högler, Erika Kague, David Karasik, Patricia Khashayar, Bente L. Langdahl, Victoria D. Leitch, Philippe Lopes, Georgios Markozannes, Fiona E. A. McGuigan, Carolina Medina-Gomez, Evangelia Ntzani, Ling Oei, Claes Ohlsson, Pawel Szulc, Jonathan H. Tobias, Katerina Trajanoska, Şansın Tuzun, Amina Valjevac, Bert van Rietbergen, Graham R. Williams, Tatjana Zekic, Fernando Rivadeneira, Barbara Obermayer-Pietsch |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Frontiers in Endocrinology, Vol 12 (2021) |
| Druh dokumentu: |
article |
| ISSN: |
1664-2392 |
| DOI: |
10.3389/fendo.2021.720728 |
| Popis: |
A synoptic overview of scientific methods applied in bone and associated research fields across species has yet to be published. Experts from the EU Cost Action GEMSTONE (“GEnomics of MusculoSkeletal Traits translational Network”) Working Group 2 present an overview of the routine techniques as well as clinical and research approaches employed to characterize bone phenotypes in humans and selected animal models (mice and zebrafish) of health and disease. The goal is consolidation of knowledge and a map for future research. This expert paper provides a comprehensive overview of state-of-the-art technologies to investigate bone properties in humans and animals – including their strengths and weaknesses. New research methodologies are outlined and future strategies are discussed to combine phenotypic with rapidly developing –omics data in order to advance musculoskeletal research and move towards “personalised medicine”. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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