| Autor: |
Jin Xu, Wen-jie Chen, Zhan Wang, Ming-yuan Xin, Shen-han Gao, Wen-jing Liu, Kai-kun Wang, Jing-wei Ma, Xin-zong Yan, Yan-ming Ren |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Proteome Science, Vol 20, Iss 1, Pp 1-13 (2022) |
| Druh dokumentu: |
article |
| ISSN: |
1477-5956 |
| DOI: |
10.1186/s12953-022-00198-y |
| Popis: |
Abstract Background Hypoxia is a risk factor for non-alcoholic fatty liver diseases, leading to permanent imbalance of liver lipid homeostasis and steatohepatitis. However, a detailed understanding of the metabolic genes and pathways involved remains elusive. Methods In vivo experiments were designed to analyze body weight and lipid metabolism changes of rats under hypoxia. After this, we combined microarray analysis and gene overexpression experiments to validate the core mechanisms involved in the response to hypoxia. Results The hypobaric hypoxia treated rats exhibited significantly increased serum triglycerides (TG) (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
|
|
Nepřihlášeným uživatelům se plný text nezobrazuje |
K zobrazení výsledku je třeba se přihlásit.
|
