Novel human melanoma brain metastasis models in athymic nude fox1nu mice: Site‐specific metastasis patterns reflecting their clinical origin

Autor:	Henrik A. Svendsen, Torstein R. Meling, Vigdis Nygaard, Stein Waagene, Hege Russnes, Siri Juell, Siril G. Rogne, Jens Pahnke, Eirik Helseth, Øystein Fodstad, Gunhild M. Mælandsmo
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	athymic nude fox1nu mice brain metastasis model human melanoma site specificity tissue‐specific metastasis Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Zdroj:	Cancer Medicine, Vol 10, Iss 23, Pp 8604-8613 (2021)
Druh dokumentu:	article
ISSN:	2045-7634
DOI:	10.1002/cam4.4334
Popis:	Abstract Background Malignant melanomas frequently metastasize to the brain, but metastases in the cerebellum are underrepresented compared with metastases in the cerebrum. Methods We established animal models by injecting intracardially in athymic nude fox1nu mice two human melanoma cell lines, originating from a cerebral metastasis (HM19) and a cerebellar metastasis (HM86). Results Using magnetic resonance imaging (MRI), metastases were first detected after a mean of 34.5 days. Mean survival time was 59.6 days for the mice in the HM86 group and significantly shorter (43.7 days) for HM19‐injected animals (p
Databáze:	Directory of Open Access Journals
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