Platelet-activating factor mediates trinitrobenzene induced dysmotility in the left colon

Autor: W. E. Longo, J. Standeven, B. Chandel, Y. Deshpande, A. M. Vernava, D. Kaminski
Jazyk: angličtina
Rok vydání: 1995
Předmět:
Zdroj: Mediators of Inflammation, Vol 4, Iss 1, Pp 17-18 (1995)
Druh dokumentu: article
ISSN: 0962-9351
1466-1861
09629351
DOI: 10.1155/S0962935195000032
Popis: We investigated whether TNB alters colonic tissue levels of PAF at the expense of changes in colonic motility in the isolated perfused rabbit left colon. Colonic inflammation was induced by the intracolonic administration of 0.25 ml of 50% ethanol containing 30 mg of trinitrobenzene. Strain gauge transducers were sewn onto the serosal surface of the colon to evaluate colonic motility. TNB administration increased tissue levels of PAF and increased the average force of each colonic contraction. Pretreatment with the PAF receptor antagonist WEB-2170 prior to TNB infusion decreased tissue concentrations of PAF and ameliorated the altered motility parameters seen with TNB alone. These results suggest that PAF is stimulated by TNB and may participate in colonic dysmotility during inflammatory states.
Databáze: Directory of Open Access Journals
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