Chain-Branched Polyhydroxylated Octahydro-1H-Indoles as Potential Leads against Lysosomal Storage Diseases

Autor:	Juan C. Estévez, Marcos A. González, M. Carmen Villaverde, Yuki Hirokami, Atsushi Kato, Fredy Sussman, David Reza, Ramón J. Estévez
Jazyk:	angličtina
Rok vydání:	2019
Předmět:	sugars iminosugars glycosidase inhibition Medicine Pharmacy and materia medica RS1-441
Zdroj:	Pharmaceuticals, Vol 12, Iss 2, p 47 (2019)
Druh dokumentu:	article
ISSN:	1424-8247
DOI:	10.3390/ph12020047
Popis:	Here, the synthesis and glycosidase inhibition properties of the two first known 3-ethyloctahydro-1H-indole-4,5,6-triols are reported. This study shows the transformation of d-glucose into polyhydroxylated 1-(2-nitrocyclohexane) acetaldehydes, followed by a protocol involving the formation of the azacyclopentane ring. Results of inhibitory potency assays and docking calculations show that at least one of them could be a lead for optimization in the search for compounds that behave like folding chaperones in lysosomal storage diseases.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/f52415d4bded4867b41f673a0748df2c Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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