Persistent activation of central amygdala CRF neurons helps drive the immediate fear extinction deficit

Autor: Yong S. Jo, Vijay Mohan K. Namboodiri, Garret D. Stuber, Larry S. Zweifel
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-020-14393-y
Popis: Learned conditioned fear associations can be weakened (extinction learning), but extinction is less effective if performed too soon after the original fear conditioning. Here, the authors show that persistent activation of CRF-expressing neurons in the central amygdala is involved in the early fear extinction deficit.
Databáze: Directory of Open Access Journals