Cytogenetics Findings in a Histiocytic Sarcoma Case
| Autor: | J. M. Alonso-Dominguez, M. Calbacho, M. Talavera, C. Villalon, L. Abalo, J. V. Garcia-Gutierrez, S. Lozano, M. Tenorio, J. Villarrubia, J. Lopez-Jimenez, M. T. Ferro |
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| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: | |
| Zdroj: | Case Reports in Hematology, Vol 2012 (2012) |
| Druh dokumentu: | article |
| ISSN: | 2090-6560 2090-6579 |
| DOI: | 10.1155/2012/428279 |
| Popis: | Histiocytic sarcoma (HS) is a neoplasm derived from histiocytes. Its diagnosis was not clear until its immunohistochemistry profile was correctly established. Not much is known about its genetic properties. We report a case of a 48-year-old male patient whose bone marrow was almost completely occupied by monomorphic medium size neoplastic cellularity. Its immunohistochemical profile was CD68+, CD4+, CD45+ with negativity of other dendritic cells, and other lineage markers. Cytogenetic study showed 4 related clones: one with trisomy 8 and extra material on the short arms of chromosome 4; a second line with tetrasomy of chromosome 8, add(4)(p16); the third clone had the same alterations as the previous and deletion of chromosome 3 at q11; the fourth line had tetrasomy 8 and translocation t(3;5)(q25;q35). To our knowledge this is the first HS case showing chromosome 8 trisomy and tetrasomy and the other described alterations. |
| Databáze: | Directory of Open Access Journals |
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