Obstructive sleep apnea is a predictor of abnormal glucose metabolism in chronically sleep deprived obese adults.
| Autor: | Giovanni Cizza, Paolo Piaggi, Eliane A Lucassen, Lilian de Jonge, Mary Walter, Megan S Mattingly, Heather Kalish, Gyorgy Csako, Kristina I Rother, Sleep Extension Study Group |
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| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: | |
| Zdroj: | PLoS ONE, Vol 8, Iss 5, p e65400 (2013) |
| Druh dokumentu: | article |
| ISSN: | 1932-6203 36559652 |
| DOI: | 10.1371/journal.pone.0065400 |
| Popis: | Sleep abnormalities, including obstructive sleep apnea (OSA), have been associated with insulin resistance.To determine the relationship between sleep, including OSA, and glucose parameters in a prospectively assembled cohort of chronically sleep-deprived obese subjects.Cross-sectional evaluation of a prospective cohort study.Tertiary Referral Research Clinical Center.Sleep duration and quality assessed by actigraphy, sleep diaries and questionnaires, OSA determined by a portable device; glucose metabolism assessed by oral glucose tolerance test (oGTT), and HbA1c concentrations in 96 obese individuals reporting sleeping less than 6.5 h on a regular basis.Sixty % of subjects had an abnormal respiratory disturbance index (RDI≥5) and 44% of these subjects had abnormal oGTT results. Severity of OSA as assessed by RDI score was associated with fasting glucose (R = 0.325, p = 0.001) and fasting insulin levels (ρ = 0.217, p = 0.033). Subjects with moderate to severe OSA (RDI>15) had higher glucose concentrations at 120 min than those without OSA (RDI |
| Databáze: | Directory of Open Access Journals |
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