Autor: |
Kizhakke M. Sathyan, Daniele Fachinetti, Daniel R. Foltz |
Jazyk: |
angličtina |
Rok vydání: |
2017 |
Předmět: |
|
Zdroj: |
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017) |
Druh dokumentu: |
article |
ISSN: |
2041-1723 |
DOI: |
10.1038/ncomms14678 |
Popis: |
Centromeres are chromosomal domains epigenetically specified by the presence of the CENP-A containing nucleosomes that control chromosome segregation. Here the authors show that α-amino trimethylation of CENP-A by the enzyme NRMT is required for centromere function, faithful chromosome segregation and cell survival. |
Databáze: |
Directory of Open Access Journals |
Externí odkaz: |
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