Inhibitory effects of pemirolast potassium and FK506 on degranulation and IL-8 production of eosinophils

Autor: Naomi Yamashita, Yasuko Akimoto, Kenji Minoguchi, Kentaro Sekine, Mikio Nakajima, Yuji Okano, Ken Ohta, Tsuyoshi Sakane
Jazyk: angličtina
Rok vydání: 1999
Předmět:
Zdroj: Allergology International, Vol 48, Iss 1, Pp 37-42 (1999)
Druh dokumentu: article
ISSN: 1323-8930
1440-1592
DOI: 10.1046/j.1440-1592.1999.00115.x
Popis: Eosinophils are the key effector cells for allergic inflammation. In order to clarify drugs which can regulate eosinophil function, we investigated the direct effect of pemirolast potassium (anti-allergic drug) and FK506 (immunosupressant) on eosinophil degranulation and cytokine production. Eosinophil degranulation induced by granulocyte-macrophage colony stimulating factor and/or platelet activating factor was inhibited from 10-4 to 10-6 mol/L pemirolast (inhibitory effect 66 and 33%, respectively) and 10-8 mol/L FK506 (inhibitory effect 45%). Pemirolast and FK506 also inhibit interleukin (IL)-8 production by eosinophil. Our data suggest that both pemirolast potassium and FK506 possess direct regulatory effects on human eosinophils and a potential to suppress allergic inflammation.
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