Insulin resistance-related features are associated with cognitive decline: a cross-sectional study in adult patients with type 1 diabetes

Autor: Xiaolin Ji, Wenjing Zou, Li Fan, Zhiguang Zhou, Xiongzhao Zhu, Xia Li
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Diabetology & Metabolic Syndrome, Vol 16, Iss 1, Pp 1-9 (2024)
Druh dokumentu: article
ISSN: 1758-5996
DOI: 10.1186/s13098-023-01249-w
Popis: Abstract Background To investigate the associations between insulin resistance (IR)-related features and cognitive function in type 1 diabetes (T1D). Methods A total of 117 adult patients with T1D were recruited in this cross-sectional study. IR-related features include overweight/obesity/central obesity, hypertension, atherogenic dyslipidemia, and decreased estimated insulin sensitivity (eIS). The Wechsler Memory Scale-Chinese Revision, Wisconsin Card Sorting Test, and Sustained Attention to Response Task was used to assess memory, executive function and sustained attention, respectively. A z-score was generated from each test, and a composite measure of global cognitive performance was calculated by averaging the z-scores of all tests. Cognitive differences were measured between T1D patients with and without IR-related features. The associations between IR-related features and and cognitive performance were analyzed using: logistic regression, partial correlation, and multivariate linear regression analysis. Results A total of 53 (45.3%) T1D patients were defined as having IR-related features. Individuals with IR-related features displayed worse overall cognitive scores compared to those without and had a 4-fold increase in the risk for having global cognitive z-score
Databáze: Directory of Open Access Journals
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