Clerodane Diterpenoids with Anti-hyperglycemic Activity from Tinospora crispa

Autor: Yuan Gao, Yan-Fen Niu, Fei Wang, Ping Hai, Fang Wang, Yin-Dong Fang, Wen-Yong Xiong, Ji-Kai Liu
Jazyk: angličtina
Rok vydání: 2016
Předmět:
Zdroj: Natural Products and Bioprospecting, Vol 6, Iss 5, Pp 247-255 (2016)
Druh dokumentu: article
ISSN: 2192-2195
2192-2209
DOI: 10.1007/s13659-016-0109-3
Popis: Abstract Four new clerodane diterpenoids, tinosporols A–C (2–4) and tinosporoside A (5), together with six known analogues were isolated from the vines of Tinospora crispa. Their structures were established by extensive spectroscopic analysis. The relative configuration at C-12 in the known diterpenoid borapetoside E (1), the major component of the plant, was firstly established with the aid of molecular model. Compound 1 significantly reduced serum glucose levels at dose-dependent manners in alloxan-induced hyperglycemic mice and db/db type 2 diabetic mice. Graphical Abstract
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