Gating intermediates reveal inhibitory role of the voltage sensor in a cyclic nucleotide-modulated ion channel

Autor: Xiaolong Gao, Philipp A. M. Schmidpeter, Vladimir Berka, Ryan J. Durham, Chen Fan, Vasanthi Jayaraman, Crina M. Nimigean
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-022-34673-z
Popis: Visualizing conformational changes during ion channel gating is crucial to understand their regulation. Here, Gao et al. capture multiple gating intermediates in a CNG channel as well as subtle, lateral voltage sensor movements necessary for channel opening.
Databáze: Directory of Open Access Journals