| Autor: |
Heindryckx Femke, Mertens Koen, Charette Nicolas, Vandeghinste Bert, Casteleyn Christophe, Van Steenkiste Christophe, Slaets Dominique, Libbrecht Louis, Staelens Steven, Starkel Peter, Geerts Anja, Colle Isabelle, Van Vlierberghe Hans |
| Jazyk: |
angličtina |
| Rok vydání: |
2010 |
| Předmět: |
|
| Zdroj: |
Molecular Cancer, Vol 9, Iss 1, p 219 (2010) |
| Druh dokumentu: |
article |
| ISSN: |
1476-4598 |
| DOI: |
10.1186/1476-4598-9-219 |
| Popis: |
Abstract Background The increasing incidence of hepatocellular carcinoma in Western countries has led to an expanding interest of scientific research in this field. Therefore, a vast need of experimental models that mimic the natural pathogenesis of hepatocellular carcinoma (HCC) in a short time period is present. The goal of our study was (1) to develop an efficient mouse model for HCC research, in which tumours develop in a natural background of fibrosis and (2) to assess the time-dependent angiogenic changes in the pathogenesis of HCC. Methods Weekly intraperitoneal injections with the hepatocarcinogenic compound N-nitrosodiethylamine was applied as induction method and samples were taken at several time points to assess the angiogenic changes during the progression of HCC. Results The N-nitrosodiethylamine-induced mouse model provides well vascularised orthotopic tumours after 25 weeks. It is a representative model for human HCC and can serve as an excellent platform for the development of new therapeutic targets. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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