A Randomized Controlled Trial of the Effect of 0.01% Atropine Eye Drops Combined with Auricular Acupoint Stimulation on Myopia Progression

Autor: Xie-He Kong, Yue Zhao, Zhi Chen, Li Zeng, Rong Han, Xiao-Qing Dong, Xiao-Cong Guo, Zheng Shi, Guang Yang, Yan-Ting Yang, Dan Zhang, Xing-Tao Zhou, Xiao-Peng Ma
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Journal of Ophthalmology, Vol 2021 (2021)
Druh dokumentu: article
ISSN: 2090-004X
2090-0058
DOI: 10.1155/2021/5585441
Popis: Background. Use of 0.01% atropine eye drops (0.01% A) is one of the most common treatments for myopia control for children in Asia. Auricular acupoint stimulation (AAS) was reported to enhance the effect of higher-concentration atropine (0.25%, 0.125%) on myopia control. This study was designed to compare the effect of 0.01% A combined with AAS and 0.01% A alone on myopia progression and choroidal thickness in children. Methods. A total of 104 children were stratified by age and randomly assigned at 1 : 1 to receive 0.01% A or 0.01% A + AAS treatment for 6 months. Repeated measurements of cycloplegic spherical equivalent (SE) autorefraction, axial length (AL), and choroidal thickness were performed at baseline, 1 month, 3 months, and 6 months. Results. The adjusted mean SE change over the 6 months was −0.38 ± 0.04 D in the 0.01% A group (n = 50) and −0.25 ± 0.04 D in the 0.01% A + AAS group (n = 50), demonstrating a significant between-group difference (P = 0.02). There was no statistically significant difference in the change of AL and choroidal thickness between the two groups (both P > 0.05). Conclusions. Adjunctive AAS compared with 0.01% A monotherapy slowed myopic progression in Chinese children by a statistically small amount, but had no effect on axial elongation and choroidal thickness during this 6-month observation. The trial is registered with ChiCTR1900021316.
Databáze: Directory of Open Access Journals
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