ATP biphasically modulates LLPS of TDP-43 PLD by specifically binding arginine residues

Autor: Mei Dang, Liangzhong Lim, Jian Kang, Jianxing Song
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
Druh dokumentu: article
ISSN: 2399-3642
50142763
DOI: 10.1038/s42003-021-02247-2
Popis: Dang Mei et al. use NMR and microscopy approaches to examine how ATP impacts the liquid-liquid phase separation (LLPS) of prion-like domains in TDP-43, a RNA-binding protein that is implicated in ALS and other neurological disorders. Their results suggest that ATP specifically binds to a subset of TDP-43 arginine residues at a particular molar ratio to modulate LLPS, and provides insight into how ATP affects the LLPS of biomolecular systems.
Databáze: Directory of Open Access Journals
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