Testing Umbilical Cords for Funisitis due to Treponema pallidum Infection, Bolivia

Autor: Jeannette Guarner, Karen Southwick, Patricia Greer, Jeanine Bartlett, Martha Fears, Ana Santander, Stanley Blanco, Victoria Pope, William Levine, Sherif Zaki
Jazyk: angličtina
Rok vydání: 2000
Předmět:
Zdroj: Emerging Infectious Diseases, Vol 6, Iss 5, Pp 487-492 (2000)
Druh dokumentu: article
ISSN: 1080-6040
1080-6059
DOI: 10.3201/eid0605.000507
Popis: To establish the frequency of necrotizing funisitis in congenital syphilis, we conducted a prospective descriptive study of maternal syphilis in Bolivia by testing 1,559 women at delivery with rapid plasma reagin (RPR). We examined umbilical cords of 66 infants whose mothers had positive RPR and fluorescent treponemal antibody absorption tests. Histologic abnormalities were detected in 28 (42%) umbilical cords (seven [11%] had necrotizing funisitis with spirochetes; three [4%] had marked funisitis without necrosis; and 18 [27%] had mild funisitis), and 38 [58%] were normal. Of 22 umbilical cords of infants from mothers without syphilis (controls), only two (9%) showed mild funisitis; the others were normal. Testing umbilical cords by using immunohistochemistry is a research tool that can establish the frequency of funisitis due to Treponema pallidum infection.
Databáze: Directory of Open Access Journals
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