Right Heart Morphology and Its Association With Excessive and Deficient Cardiac Visceral Adipose Tissue

Autor: Domagoj Vučić, Nikola Bijelić, Edi Rođak, Jasmina Rajc, Boris Dumenčić, Tatjana Belovari, Damir Mihić, Kristina Selthofer-Relatić
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Clinical Medicine Insights: Cardiology, Vol 15 (2021)
Druh dokumentu: article
ISSN: 1179-5468
11795468
DOI: 10.1177/11795468211041330
Popis: Visceral adipose tissue is an independent risk factor for the development of atherosclerotic coronary disease, arterial hypertension, diabetes and metabolic syndrome. Right heart morphology often involves the presence of adipose tissue, which can be quantified by non-invasive imaging methods. The last decade brought a wealth of new insights into the function and morphology of adipose tissue, with great emphasis on its role in the pathogenesis of heart disease. Cardiac adipose tissue is involved in thermogenesis, mechanical protection of the heart and energy storage. However, it can also be an endocrine organ that synthesises numerous pro-inflammatory and anti-inflammatory cytokines, the effect of which is accomplished by paracrine and vasocrine mechanisms. Visceral adipose tissue has several compartments that differ in their embryological origin and vascularisation. Deficiency of cardiac adipose tissue, often due to chronic pathological conditions such as oncological diseases or chronic infectious diseases, predicts increased mortality and morbidity. To date, knowledge about the influence of visceral adipose tissue on cardiac morphology is limited, especially the effect on the morphology of the right heart in a state of excess or deficient visceral adipose tissue.
Databáze: Directory of Open Access Journals
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