Study on blood oxygen level-dependent magnetic resonance imaging for the assessment of early renal hypoxia in chronic kidney disease

Autor: HUANG Juan, ZHU Xiaolei, LI Xiao, CHEN Kemin, YAN Fuhua, XU Xueqin
Jazyk: čínština
Rok vydání: 2022
Předmět:
Zdroj: Zhenduanxue lilun yu shijian, Vol 21, Iss 03, Pp 385-389 (2022)
Druh dokumentu: article
ISSN: 1671-2870
DOI: 10.16150/j.1671-2870.2022.03.016
Popis: Objective: To evaluate value of blood oxygen level-dependent (BOLD) magnetic resonance imaging (MRI) for early renal hypoxia assessment in chronic kidney disease(CKD). Methods: Fifty-two patients with CKD and 52 age- and sex-matched health volunteers underwent BOLD MRI of the kidneys. Serum creatinine (sCr) levels and estimated GFR (eGFR) were collected. The patients were classified into 5 stages according to the National Kidney Foundation′s Kidney Disease Outcomes Quality Initiative. Difference in R2*s were compared between patients and volunteers and among different stages of CKD. Results: In patients with CKD and volunteers, R2* of renal medulla was higher than that of renal cortex (P0.05). However, medullar R2*s were lower in patients with CKD1 [(16.55 ± 2.12)/s], CKD4 [(16.48 ± 2.95)/s], or CKD5 [(13.99 ± 2.21)/s] than those in volunteers [(18.17± 2.38)/s] (P
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