| Autor: |
E. Shinto, J. Omata, A. Sikina, A. Sekizawa, Y. Kajiwara, K. Hayashi, Y. Hashiguchi, K. Hase, H. Ueno |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
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| Zdroj: |
BJS Open, Vol 4, Iss 2, Pp 301-309 (2020) |
| Druh dokumentu: |
article |
| ISSN: |
2474-9842 |
| DOI: |
10.1002/bjs5.50251 |
| Popis: |
Background Reduced expression of cluster of differentiation (CD) 133 and cyclo‐oxygenase (COX) 2, and increased density of CD8+ tumour‐infiltrating lymphocytes, are associated with a favourable tumour response to preoperative chemoradiotherapy (CRT). This study aimed to evaluate these markers in relation to tumour response after preoperative CRT in two rectal cancer cohorts. Methods Patients with low rectal cancer who underwent radical resection and preoperative short‐term CRT in 2001–2007 (retrospective cohort) and long‐term CRT in 2011–2017 (prospective cohort) were analysed. Pretreatment biopsies were stained immunohistochemically using antibodies to determine CD133 and COX‐2 expression, and increased CD8+ density. Outcome measures were tumour regression grade (TRG), tumour downstaging and survival. Results For 95 patients in the retrospective cohort, the incidence of TRG 3–4 was 67 per cent when two or three immunohistochemistry (IHC) features were present, but only 20 per cent when there were fewer features (P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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