Resorcinol Compounds Isolated form the Bark of Myristica fatua Houtt.

Autor:	Megawati, Akhmad Darmawan
Jazyk:	angličtina
Rok vydání:	2017
Předmět:	Myristica fatua Houtt. resorcinol malabaricone B malabaricone C Pharmacy and materia medica RS1-441
Zdroj:	Indonesian Journal of Pharmacy, Vol 28, Iss 2, Pp 82-90 (2017)
Druh dokumentu:	article
ISSN:	2338-9427 2338-9486
DOI:	10.14499/indonesianjpharm28iss2pp82
Popis:	Myristica fatua Houtt. is one of the endemic plants growth in Wallace region. Isolation of the secondary metabolite compounds from the ethyl acetate fraction of the bark of Myristica fatua Houtt. has been done using some chromatography techniques afforded two resorcinol compounds, malabaricone C (1), and malabaricone B (2). The structures of 1-2 were determined using spectroscopic techniques, including mass spectrometry, 1D-NMR and 2D-NMR. Both compounds showed in vitro cytotoxic activity against the breast carcinoma cancer cell lines MCF-7 using alamar blue assay method, with IC50 of 2.38 and 0.71 μg/mL, respectively.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/f488e67aab8b48bcb9ec28dc1587f7e0 Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF