DNA methylation in mice is influenced by genetics as well as sex and life experience
| Autor: | Sara A. Grimm, Takashi Shimbo, Motoki Takaku, James W. Thomas, Scott Auerbach, Brian D. Bennett, John R. Bucher, Adam B. Burkholder, Frank Day, Ying Du, Christopher G. Duncan, John E. French, Julie F. Foley, Jianying Li, B. Alex Merrick, Raymond R. Tice, Tianyuan Wang, Xiaojiang Xu, NISC Comparative Sequencing Program, Pierre R. Bushel, David C. Fargo, James C. Mullikin, Paul A. Wade |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: | |
| Zdroj: | Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019) |
| Druh dokumentu: | article |
| ISSN: | 2041-1723 45965315 |
| DOI: | 10.1038/s41467-018-08067-z |
| Popis: | DNA methylation is an epigenetic mark involved in gene regulation. Here the authors investigate the extent to which genetics, sex and pregnancy influence genomic DNA methylation in mice, providing evidence of the stability of CpG methylation across generation and suggest that CpG methylation may serve as an epigenetic record of life events in somatic tissues at loci whose expression is linked to the relevant biology. |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
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