| Autor: |
Ditte Marie Jensen, Gry Freja Skovsted, Mathilde Frederikke Bjørn Bonde, Jacob Fog Bentzon, Bidda Rolin, Grégory Franck, Maria Katarina Elm Ougaard, Louise Marie Voetmann, Julian Christoffer Bachmann, Anna Uryga, Charles Pyke, Rikke Kaae Kirk, Henning Hvid, Lotte Bjerre Knudsen, Jens Lykkesfeldt, Michael Nyberg |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Atherosclerosis Plus, Vol 49, Iss , Pp 32-41 (2022) |
| Druh dokumentu: |
article |
| ISSN: |
2667-0895 |
| DOI: |
10.1016/j.athplu.2022.05.004 |
| Popis: |
Background and aims: Randomized clinical studies have shown a reduction in cardiovascular outcomes with glucagon-like peptide 1 receptor agonist (GLP-1RA) treatment with the hypothesized mechanisms being an underlying effect on atherosclerosis. Here, we aimed to assess the pharmacological effects of semaglutide in an atheroprone murine model that recapitulates central mechanisms related to vascular smooth muscle cell (VSMC) phenotypic switching and endothelial dysfunction known to operate within the atherosclerotic plaque. Methods: In study A, we employed an electrical current to the carotid artery in ApoE−/− mice to induce severe VSMC injury and death, after which the arteries were allowed to heal for 4 weeks. In study B, a constrictive cuff was added for 6 h at the site of the healed segment to induce a disturbance in blood flow. Results: Compared to vehicle, semaglutide treatment reduced the intimal and medial area by ∼66% (p = 0.007) and ∼11% (p = 0.0002), respectively. Following cuff placement, expression of the pro-inflammatory marker osteopontin and macrophage marker Mac-2 was reduced (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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