| Autor: |
Filippo Carboni, Roberta Cozzi, Giacomo Romagnoli, Giovanna Tuscano, Cristiana Balocchi, Giada Buffi, Margherita Bodini, Cecilia Brettoni, Fabiola Giusti, Sara Marchi, Giulia Brogioni, Barbara Brogioni, Paolo Cinelli, Luigia Cappelli, Chiara Nocciolini, Silvia Senesi, Claudia Facciotti, Elisabetta Frigimelica, Monica Fabbrini, Daniela Stranges, Silvana Savino, Domenico Maione, Roberto Adamo, Benjamin Wizel, Immaculada Margarit, Maria Rosaria Romano |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
npj Vaccines, Vol 8, Iss 1, Pp 1-10 (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2059-0105 |
| DOI: |
10.1038/s41541-023-00744-5 |
| Popis: |
Abstract A maternal vaccine to protect neonates against Group B Streptococcus invasive infection is an unmet medical need. Such a vaccine should ideally be offered during the third trimester of pregnancy and induce strong immune responses after a single dose to maximize the time for placental transfer of protective antibodies. A key target antigen is the capsular polysaccharide, an anti-phagocytic virulence factor that elicits protective antibodies when conjugated to carrier proteins. The most prevalent polysaccharide serotypes conjugated to tetanus or diphtheria toxoids have been tested in humans as monovalent and multivalent formulations, showing excellent safety profiles and immunogenicity. However, responses were suboptimal in unprimed individuals after a single shot, the ideal schedule for vaccination during the third trimester of pregnancy. In the present study, we obtained and optimized self-assembling virus-like particles conjugated to Group B Streptococcus capsular polysaccharides. The resulting glyco-nanoparticles elicited strong immune responses in mice already after one immunization, providing pre-clinical proof of concept for a single-dose vaccine. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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Full text from SpringerLink