| Autor: |
Hanan M. Alharbi, Afrah F. Alkhuriji, Suliman Y. Alomar, Zainb A. Babay, Alaa A. Alnafjan, Hussah M. Alobaid, Wazirah G. Allharbi, Lamjed A. Mansour |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Journal of King Saud University: Science, Vol 34, Iss 4, Pp 102034- (2022) |
| Druh dokumentu: |
article |
| ISSN: |
1018-3647 |
| DOI: |
10.1016/j.jksus.2022.102034 |
| Popis: |
Aims: The primary aim of the current study is to decide if genetic polymorphisms of the killer immunoglobulin-like receptor (KIR) and human leukocyte antigen (HLA-C) genes are related to recurrent spontaneous abortion (RSA) in the Saudi women who are affected with polycystic ovarian syndrome (PCO) and in PCO patients without RSA. Materials and methods: The study was conducted in Riyadh and included 199 cases divided as follows: 69 PCO Saudi women with an RSA history, i.e. three or more spontaneous abortion cases, 65 patients were exclusively with PCO and 65 healthy controls, typed for 17 KIR genes and the HLA-C1 and HLA-C2 allotypes using polymerase chain reaction-sequence-specific primer methodology. Results: The study reported that the recurrences of KIR3DL1, 2DS4ins, 2DL2, and KIR2DS2 significantly reduced among RSA-PCO women in comparison with healthy controls (OR = 337.45, 39.08, 2.4, 4.59 with p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
|
