Autor: |
Peng He, Xing Zhang, Ke Xia, Dixy E. Green, Sultan Baytas, Yongmei Xu, Truong Pham, Jian Liu, Fuming Zhang, Andrew Almond, Robert J. Linhardt, Paul L. DeAngelis |
Jazyk: |
angličtina |
Rok vydání: |
2022 |
Předmět: |
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Zdroj: |
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022) |
Druh dokumentu: |
article |
ISSN: |
2041-1723 |
DOI: |
10.1038/s41467-022-34788-3 |
Popis: |
Heparin is a family of complex carbohydrates binding to proteins to modulate cell activities. Here the authors report the synthesis, and conformations simulations of S-linked hemi-A heparosan [GlcA-S-GlcNAc]n, a thio-glycosidic uncleavable polysaccharide, and test it as human heparanase inhibitor. |
Databáze: |
Directory of Open Access Journals |
Externí odkaz: |
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