Regional oxidative stress in encephalon of female mice with polyphenolic exposure from tea extracts in oral overweight plant-based treatment
| Autor: | Agustin Ramiro Miranda, Maria Cecilia Cittadini, Claudia Albrecht, Elio Andrés Soria |
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| Jazyk: | English<br />Spanish; Castilian<br />Portuguese |
| Rok vydání: | 2017 |
| Předmět: | |
| Zdroj: | Revista de la Facultad de Ciencias Médicas de Córdoba, Vol 74, Iss 3, Pp 197-202 (2017) |
| Druh dokumentu: | article |
| ISSN: | 0014-6722 1853-0605 |
| DOI: | 10.31053/1853.0605.v74.n3.14815 |
| Popis: | Polyphenols provide by diet may act as antioxidant in the Central Nervous System and exert a protective effect on metabolic diseases. The aim of this study was to establish tea extract effects on oxidative status and murine overweight in accordance with polyphenolic availability in different encephalic regions. Methods: Balb/c mice (female, n>3) with overweight received for 15 days 100 mg/Kg/d of extract from Lantana grisebachii, Aspidosperma quebracho-blanco, or Ilex paraguariensis extracts and control group (received water without extract). Body weight gain was recorded regularly. Polyphenols, hydroperoxides (HP), lipid peroxides (LP), and superoxide anion (SO) were measured in brain (telencephalon and diencephalon), midbrain, brainstem and cerebellum. Results were compared by ANOVA followed by the Tukey test (PA. quebracho-blanco-based treatment decreased weight gain and increased polyphenols in brainstem (pL. grisebachii-based treatment reduced oxidative markers differentially in each region (pI. paraguariensis-based treatment oxidized midbrain and cerebellum, although it was antioxidant in the brainstem (pA. quebracho-blanco extract was active on overweight and increased polyphenols in brainstem, with safe functional derivatives being required to avoid oxidative stress. Other extracts affected oxidative status in a region-dependent manner. |
| Databáze: | Directory of Open Access Journals |
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