| Autor: |
Masashi Nagao, Yoshitomo Saita, Muneaki Ishijima, Yohei Kobayashi, Keiji Kobayashi, Haruka Kaneko, Hirofumi Nishio, Yasumasa Momoi, Ryosuke Nakajima, Sayuri Uchino, Takanori Wakayama, Shin Fukusato, Suguru Wakana, Jun Tomura, Keiichi Yoshida, Mitsuaki Kubota |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
BMJ Open, Vol 12, Iss 11 (2022) |
| Druh dokumentu: |
article |
| ISSN: |
2044-6055 |
| DOI: |
10.1136/bmjopen-2022-061484 |
| Popis: |
Introduction The elevated cytokine levels in patients suffering from anterior cruciate ligament (ACL) rupture may lead to acute post-traumatic arthritis (APTA) and post-traumatic osteoarthritis (PTOA). Due to its chondrogenerative and anti-inflammatory effect, platelet-rich plasma (PRP) therapy is expected to show a positive outcome in APTA and PTOA. The proposed trial aims to quantitatively measure the efficacy of PRP injection in arresting post-traumatic cartilage degeneration among patients after ACL reconstruction.Methods and analysis This will be a single-blind, randomised, prospective, controlled clinical trial designed following the Consolidated Standards of Reporting Trials guidelines. After ACL reconstruction, 80 patients will be randomised to receive either leucocyte-poor PRP injection after joint aspiration or a placebo control group receiving only joint aspiration. Participants (age 20–49 years) will be those who have undergone ACL reconstruction within the past 2 weeks with a body mass index |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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