A global online study of haematopoietic stem cell transplantation in multiple sclerosis and other neurodegenerative disorders

Autor: Peter K. Panegyres, Jodi Russell, Huei‐Yang Chen, Mariella Panegyres
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Chronic Diseases and Translational Medicine, Vol 9, Iss 1, Pp 39-43 (2023)
Druh dokumentu: article
ISSN: 2589-0514
DOI: 10.1002/cdt3.44
Popis: Abstract Background The objective of this study was to understand the uptake of hemopoietic stem cell transplantation (HSCT) in neuroimmunological disorders like multiple sclerosis (MS). Method An independent University affiliated research organization conducted a global online survey of people having had HSCT, examining demographics, treatment protocol, and effectiveness. Results Of 271 participants, useful data were available in 223; women aged 35–54 accounted for 73.5%. Most had a household income greater than US$50,000, and the majority of participants were from Australia and the United States. Nearly 94.6% of people suffer from MS. Most had their treatment in Russia (38.7%) and 78.1% had nonmyeloablative transplants. Nearly half of the participants spent between US$50,000 to US$74,999. There were 54.5% of neurologists who did not support their patients having HSCT. Around 85.5% of participants believed HSCT helped them manage their disease from weeks to years after transplantation, and treatment was recommended by 9.5% of participants. The average reduction in Expanded Disability Status Score after transplantation was 1.2 (95% CI: 0.97–1.41; N = 197; p
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