| Autor: |
Fernanda Paula Cavalcante, Ana Maria Mendonça Coelho, Marcel Cerqueira Cesar Machado, Sandra Nassa Sampietre, Rosely Antunes Patzina, Márcio Augusto Diniz, Eleazar Chaib, Luiz Augusto Carneiro D'Albuquerque |
| Jazyk: |
angličtina |
| Rok vydání: |
2015 |
| Předmět: |
|
| Zdroj: |
Acta Cirúrgica Brasileira, Vol 30, Iss 11, Pp 749-755 (2015) |
| Druh dokumentu: |
article |
| ISSN: |
0102-8650 |
| DOI: |
10.1590/S0102-865020150110000005 |
| Popis: |
PURPOSE: To evaluate the underlying mechanisms by which sevoflurane protects the liver against ischemia/reperfusion injury evaluate the mechanism by which sevoflurane exerts this protective effect. METHODS: Twenty-six rats were subjected to partial ischemia/reperfusion injury for 1h: one group received no treatment, one group received sevoflurane, and sham group of animals received laparotomy only. Four hours after reperfusion, levels of alanine and aspartate aminotransferases, tumor necrosis factor-a, and interleukins 6 and 10 were measured. Analyses of mitochondrial oxidation and phosphorylation, malondialdehyde content, histology, and pulmonary vascular permeability were performed. RESULTS: Serum levels of alanine and aspartate aminotransferases were significantly lower in the sevoflurane group compared to untreated controls (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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