Arginine methylation catalyzed by PRMT1 is required for B cell activation and differentiation

Autor: Simona Infantino, Amanda Light, Kristy O’Donnell, Vanessa Bryant, Danielle T. Avery, Michael Elliott, Stuart G. Tangye, Gabrielle Belz, Fabienne Mackay, Stephane Richard, David Tarlinton
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Zdroj: Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-017-01009-1
Popis: PRMT1 is an arginine methyltransferase involved in a variety of cell functions. Here the authors delete PRMT1 specifically in mature B cells to show the importance of arginine methylation for B cell proliferation, differentiation and survival, and thereby for humoral immunity.
Databáze: Directory of Open Access Journals