| Autor: |
Jia Su, Qinglin Yu, Hao Zhu, Xiaojing Li, Hanbin Cui, Weiping Du, Lindan Ji, Maoqing Tong, Yibo Zheng, Hongyu Xu, Jianjiang Zhang, Yunyun Zhu, Yezi Xia, Ting Liu, Qi Yao, Jun Yang, Xiaomin Chen, Jingbo Yu |
| Jazyk: |
angličtina |
| Rok vydání: |
2017 |
| Předmět: |
|
| Zdroj: |
PLoS ONE, Vol 12, Iss 3, p e0174511 (2017) |
| Druh dokumentu: |
article |
| ISSN: |
1932-6203 |
| DOI: |
10.1371/journal.pone.0174511 |
| Popis: |
The goal of our study was to investigate the contribution of ABCB1 expression to the risk of clopidogrel resistance (CR). Platelets functions were measured using the Verify-Now P2Y12 assay. Applying Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP), the single-nucleotide polymorphisms (SNPs) was tested. Using bisulphite pyrosequencing assay, we investigated the association of the ABCB1 DNA methylation levels and CR. It was shown that female, hypertension, and lower albumin levels increased the risk of CR (P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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