| Autor: |
Guido J. Bakker, Johan G. Schnitzler, Siroon Bekkering, Nicolien C. deClercq, Annefleur M. Koopen, Annick V. Hartstra, Emma C. E. Meessen, Torsten P. Scheithauer, Maaike Winkelmeijer, Geesje M. Dallinga‐Thie, Patrice D. Cani, Elles Marleen Kemper, Maarten R. Soeters, Jeffrey Kroon, Albert K. Groen, Daniël H. vanRaalte, Hilde Herrema, Max Nieuwdorp |
| Jazyk: |
angličtina |
| Rok vydání: |
2019 |
| Předmět: |
|
| Zdroj: |
Physiological Reports, Vol 7, Iss 16, Pp n/a-n/a (2019) |
| Druh dokumentu: |
article |
| ISSN: |
2051-817X |
| DOI: |
10.14814/phy2.14199 |
| Popis: |
Abstract Intake of a high‐fat meal induces a systemic inflammatory response in the postprandial which is augmented in obese subjects. However, the underlying mechanisms of this response have not been fully elucidated. We aimed to assess the effect of gut microbiota modulation on postprandial inflammatory response in lean and obese subjects. Ten lean and ten obese subjects with metabolic syndrome received oral vancomycin 500 mg four times per day for 7 days. Oral high‐fat meal tests (50 g fat/m2 body surface area) were performed before and after vancomycin intervention. Gut microbiota composition, leukocyte counts, plasma lipopolysaccharides (LPS), LPS‐binding protein (LBP), IL‐6 and MCP‐1 concentrations and monocyte CCR2 and cytokine expression were determined before and after the high‐fat meal. Oral vancomycin treatment resulted in profound changes in gut microbiota composition and significantly decreased bacterial diversity in both groups (phylogenetic diversity pre‐ versus post‐intervention: lean, 56.9 ± 7.8 vs. 21.4 ± 6.6, P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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