| Autor: |
Chen Zhan, Rong Xu, Bizhou Li, Jiaxing Liu, Wanqin Liang, Shengfang Zhang, Liman Fang, Shuxin Zhong, S. Dushinka Shaniya Helen de Silva, Dhinesan Sivapalan, Wei Luo, Jing Li, Kefang Lai, Nanshan Zhong, Roma Sehmi, Paul M. O’Byrne, Ruchong Chen |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Frontiers in Immunology, Vol 13 (2022) |
| Druh dokumentu: |
article |
| ISSN: |
1664-3224 |
| DOI: |
10.3389/fimmu.2022.737968 |
| Popis: |
ObjectiveThis study aims to explore the potential of in situ airway differentiation of eosinophil progenitors (EoPs) and hematopoietic progenitor cells (HPCs) in sputum and peripheral blood from patients with non-asthmatic eosinophilic bronchitis (NAEB), eosinophilic asthma (EA), and healthy controls (HC).MethodsUsing flow cytometry, we enumerated sputum and blood HPCs and EoPs in patients with NAEB (n=15), EA (n=15), and HC (n=14) at baseline. Patients with NAEB and EA were then treated for 1 month with budesonide (200 μg, bid) or budesonide and formoterol (200/6 μg, bid), respectively. HPCs and EoPs in both compartments were re-evaluated.ResultsAt baseline, NAEB and EA both had significantly greater numbers of sputum but not blood HPCs and EoPs (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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