| Autor: |
Al-Shazly Gaber Mohamed Galal, Reham M. Dawood, Mostafa K. El Awady, Yasser Mohamed Mohamed El-Dessouky, Mohamed Mahmoud Abdel-Halim Mahmoud, Mohamed Darwish Ahmed Abd Alla |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
Journal of Genetic Engineering and Biotechnology, Vol 21, Iss 1, Pp 1-8 (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2090-5920 |
| DOI: |
10.1186/s43141-023-00544-3 |
| Popis: |
Abstract Background and aims Predictors of chronic HCV response to oral antiviral therapy (OAT) are related to host genetic variations. Single nucleotide polymorphisms (SNP) and alleles variations of host genes in association with hepatic fibro-cirrhotic changes have a distinct role in OAT outcomes. The current research evaluated the association of Cirrhosis-Risk-Scores (CRS) values, based on the correlation of seven genes signature-SNPs, with sonographic liver parenchymal changes in determining OAT outcomes. Methods All study subjects (n = 54) were recruited three months after completing OAT and classified into three groups. Group I (n = 21) had negative HCV PCR, group II (n = 17) showed positive solitary intra-PBMCs HCV infection, and group III(n = 16) was serum HCV RNA PCR-positive. All study-population were subjected to examination by hepatic-ultrasound (US), FIB-4-scoring, and screening for 7 gene-signature that addressed CRS values as low, intermediate, and high depending on gene SNPs identification. Results Group I showed a significant association with low CRS values compared to other groups (P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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