Can leucine supplementation attenuate muscle atrophy? A literature review
| Autor: | Rafael Bruno Do Amaral, Carlos Eduardo Carvalho Martins, Antonio Herbert Lancha Junior, Vitor de Salles Painelli |
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| Jazyk: | English<br />Portuguese |
| Rok vydání: | 2015 |
| Předmět: | |
| Zdroj: | Revista Brasileira de Cineantropometria e Desempenho Humano, Vol 17, Iss 4, Pp 496-506 (2015) |
| Druh dokumentu: | article |
| ISSN: | 1415-8426 1980-0037 |
| DOI: | 10.5007/1980-0037.2015v17n4p496 |
| Popis: | Currently, there has been new expectations in studying strategies with the potential to mitigate the skeletal muscle atrophy that characterizes conditions such as aging, disuse, cancer, and the use of certain medications. Among them, amino acid leucine has received special attention due to its potential to stimulate specific pathways of protein synthesis in skeletal muscle. Due to the wide spread use of this amino acid by the media, several studies have been aimed at investigating the possible effectiveness of leucine against skeletal muscle atrophy. As a result, this literature review was aimed to analyze recent studies that investigated the effects of leucine supplementation on skeletal muscle atrophy in both humans and animals. Overall, the wide variations in the experimental designs developed, models studied, leucine dose, treatment duration and sample healthiness make it difficult for professionals and researchers to establish guidelines about possible therapeutic effectiveness of this nutritional strategy. |
| Databáze: | Directory of Open Access Journals |
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