Synthesis of limonene β-amino alcohol derivatives in support of new antileishmanial therapies

Autor:	Stela R Ferrarini, Cedric S Graebin, Jones Limberger, Rômulo FS Canto, Daiane O Dias, Ricardo G da Rosa, Maria de Fátima Madeira, Vera L Eifler-Lima
Jazyk:	angličtina
Rok vydání:	2008
Předmět:	limonene β-amino alcohol synthesis leishmaniasis Leishmania braziliensis neglected diseases Microbiology QR1-502 Infectious and parasitic diseases RC109-216
Zdroj:	Memorias do Instituto Oswaldo Cruz, Vol 103, Iss 8, Pp 773-777 (2008)
Druh dokumentu:	article
ISSN:	0074-0276 1678-8060
DOI:	10.1590/S0074-02762008000800005
Popis:	A series of seven limonene β-amino alcohol derivatives has been regioselectively synthesised in moderate to good yields. Two of these compounds were found to be significantly effective against in vitro cultures of the Leishmania (Viannia) braziliensis promastigote form in the micromolar range. The activities found for 3b and 3f were about 100-fold more potent than the standard drug, Pentamidine, in the same test, while limonene did not display any activity. This is the first report of antileishmanial activity by limonene β-amino alcohol derivatives.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/f4128a8993ca4478982625dd7019505f Zobrazit plný text záznamu View record in DOAJ