Associations between airborne crude oil chemicals and symptom-based asthma

Autor: Kaitlyn G. Lawrence, Nicole M. Niehoff, Alexander P. Keil, W. Braxton Jackson, II, Kate Christenbury, Patricia A. Stewart, Mark R. Stenzel, Tran B. Huynh, Caroline P. Groth, Gurumurthy Ramachandran, Sudipto Banerjee, Gregory C. Pratt, Matthew D. Curry, Lawrence S. Engel, Dale P. Sandler
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Environment International, Vol 167, Iss , Pp 107433- (2022)
Druh dokumentu: article
ISSN: 0160-4120
DOI: 10.1016/j.envint.2022.107433
Popis: Rationale: The 2010 Deepwater Horizon (DWH) oil spill response and cleanup (OSRC) workers were exposed to airborne total hydrocarbons (THC), benzene, toluene, ethylbenzene, o-, m-, and p-xylenes and n-hexane (BTEX-H) from crude oil and PM2.5 from burning/flaring oil and natural gas. Little is known about asthma risk among oil spill cleanup workers. Objectives: We assessed the relationship between asthma and several oil spill-related exposures including job classes, THC, individual BTEX-H chemicals, the BTEX-H mixture, and PM2.5 using data from the Gulf Long-Term Follow-up (GuLF) Study, a prospective cohort of 24,937 cleanup workers and 7,671 nonworkers following the DWH disaster. Methods: Our analysis largely focused on the 19,018 workers without asthma before the spill who had complete exposure, outcome, and covariate information. We defined incident asthma 1–3 years following exposure using both self-reported wheeze and self-reported physician diagnosis of asthma. THC and BTEX-H were assigned to participants based on measurement data and work histories, while PM2.5 used modeled estimates. We used modified Poisson regression to estimate risk ratios (RR) and 95% confidence intervals (CIs) for associations between spill-related exposures and asthma and a quantile-based g-computation approach to explore the joint effect of the BTEX-H mixture on asthma risk. Results: OSRC workers had greater asthma risk than nonworkers (RR: 1.60, 95% CI: 1.38, 1.85). Higher estimated THC exposure levels were associated with increased risk in an exposure-dependent manner (linear trend test p
Databáze: Directory of Open Access Journals
Externí odkaz: