Increased Expression of Inflammatory Cytokines and Discogenic Neck Pain

Autor: Xinjian Kang, Man Qian, Tao Qin, Mingli Liu, Haiwei Xu, Baoshan Xu
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Orthopaedic Surgery, Vol 16, Iss 1, Pp 227-233 (2024)
Druh dokumentu: article
ISSN: 1757-7861
1757-7853
DOI: 10.1111/os.13963
Popis: Objective Although neck pain has become a serious economic and social problem worldwide, the etiology remains poorly understood. The aim of current study is to explore the possible pathogenesis of discogenic neck pain by analyzing the relationship between inflammatory cytokines and discogenic neck pain and provide a valuable reference for the prevention and treatment of discogenic neck pain. Methods A total of 111 cervical disc samples were collected between October 1, 2021, and October 1, 2022: 38 samples from the discogenic neck pain group, 41 samples from the symptomatic control group, and 32 samples from the normal control group. The concentration of nitric oxide (NO), interleukin (IL)‐1, interleukin (IL)‐6, and tumor necrosis factor alpha (TNF‐α) was determined using the enzyme‐linked immunosorbent assay in each sample, and the degeneration degree of the target discs were evaluated using T2‐weighted sagittal magnetic resonance imaging (MRI) according to the Miyazaki disc degeneration grading system. Whether the differences among the three groups were statistically significant was tested using one‐way analysis of variance and an unpaired t‐test, respectively. Results The differences of the baseline characteristics were not statistically significant between the discogenic neck pain group and the symptomatic control group (p > 0.05). The expression of inflammatory cytokines in disc samples from the discogenic neck pain group (NO: 9.89 ± 1.75, IL‐1β: 10.74 ± 1.92, IL‐6:31.65 ± 2.46, and TNF‐α: 5.96 ± 1.91) was increased in comparison with the disc samples from both the symptomatic control group (NO: 7.15 ± 2.78, IL‐1β: 8.03 ± 1.87, IL‐6: 25.79 ± 2.12, and TNF‐α: 4.18 ± 2.87) and the normal control group (NO: 6.11 ± 1.37, IL‐1β: 5.84 ± 2.25, IL‐6: 20.65 ± 1.26, and TNF‐α: 2.05 ± 0.58). The differences were statistically significant (p
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