| Autor: |
David E. Shoup |
| Jazyk: |
angličtina |
| Rok vydání: |
2016 |
| Předmět: |
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| Zdroj: |
AIMS Biophysics, Vol 3, Iss 4, Pp 522-528 (2016) |
| Druh dokumentu: |
article |
| ISSN: |
2377-9098 |
| DOI: |
10.3934/biophy.2016.4.522 |
| Popis: |
The Berg-Purcell expression for the diffusion-controlled binding rate to N sites uniformly distributed on the surface of a sphere is generalized to clusters of receptors located at the poles of a cell. By replacing a partially reactive surface with one that is covered with N circular sites that act independently, one can derive analytic expressions for the diffusion-controlled rate constant for clusters of binding sites. This has application to systems where the reactive sites are located in a specific region or regions on the surface of the protein or cell. These include peptide hormones reacting with target receptors, protein-ligand reactions and bacterial chemotaxis. Multiple sensory receptors both at one and two poles of a sphere are studied. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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