Comparative Study of Antiviral Activity of Luteolin and 7,3’-Disulfate Luteolin

Autor: N. V. Krylova, A. M. Popov, G. N. Leonova, A. А. Artyukov, O. S. Maistrovskaya
Jazyk: ruština
Rok vydání: 2020
Předmět:
Zdroj: Антибиотики и Химиотерапия, Vol 56, Iss 11-12, Pp 7-10 (2020)
Druh dokumentu: article
ISSN: 0235-2990
Popis: Antiviral activity of 7,3’-disulfate luteolin, extracted from Zostera marina was studied on an experimental model of tick-borne encephalitis (TBE) in vivo and in vitro. The drug increased the survival of the experimental mice infected with TBE virus and prolonged their lifespan. It was shown that 7,3’-disulfate luteolin reduced the virus accumulation in the SPEV cells by 2.0-4.0 lg TCID50/ml.
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