Geographical Variations in Patients with Heart Failure and Preserved Ejection Fraction: A Sub-Group Analysis of the APOLLON Registry

Autor: Bülent Özlek, Eda Özlek, Hicaz Zencirkıran Ağuş, Mehmet Tekinalp, Serkan Kahraman, Oğuzhan Çelik, Cem Çil, Özcan Başaran, Volkan Doğan, Bedri Caner Kaya, İbrahim Rencüzoğulları, Altuğ Ösken, Lütfü Bekar, Mustafa Ozan Çakır, Yunus Çelik, Kadir Uğur Mert, Kadriye Memiç Sancar, Samet Sevinç, Gurbet Özge Mert, Murat Biteker
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: Balkan Medical Journal, Vol 36, Iss 4, Pp 235-244 (2019)
Druh dokumentu: article
ISSN: 2146-3123
2146-3131
DOI: 10.4274/balkanmedj.galenos.2019.2019.2.17
Popis: Background: Clinical characteristics of patients with heart failure may vary geographically. However, limited data are available regarding the geographical differences of patients with heart failure and preserved ejection fraction. Aims: The present subgroup analysis aims to investigate the geographical differences in clinical characteristics, management, and primary etiology of patients with heart failure and preserved ejection fraction in Turkey. Study Design: A cross-sectional study. Methods: A comPrehensive, ObservationaL registry of heart faiLure with mid-range and preserved ejection fractiON (APOLLON) is a multicenter and observational study conducted in seven regions of Turkey (NCT03026114). The present study is a post-hoc analysis of the APOLLON registry. In this substudy, we compared the clinical characteristics of 819 consecutive patients with heart failure and preserved ejection fraction (mean age, 67 years; 57.8% women) admitted to cardiology outpatient units in different geographical regions. Results: Based on the geographical distribution of the entire Turkish population, the highest number of patients enrolled were from Marmara (271 patients, 33.1%). All demographical characteristics, clinical and laboratory findings, comorbidities, primary etiology, and medications prescribed were significantly different between the regions. Furthermore, inter-regional gender differences were identified. Comparatively, the Aegean and Mediterranean regions had older patients with heart failure and preserved ejection fraction (p
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