Scattering-Angle-Resolved Optical Coherence Tomography of a Hypoxic Mouse Retina Model

Autor: Michael R Gardner, Ayesha S Rahman, Thomas E Milner, Henry G Rylander
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: Journal of Experimental Neuroscience, Vol 13 (2019)
Druh dokumentu: article
ISSN: 1179-0695
11790695
DOI: 10.1177/1179069519837564
Popis: Several studies have noted a correlation between retinal degeneration and traumatic encephalopathy (TE) making the retina a leading candidate for detection and assessment. Scattering-angle-resolved optical coherence tomography (SAR-OCT) is a candidate imaging modality to detect sub-resolution changes in retinal microstructure. SAR-OCT images of murine retinas that experience a hypoxic insult—euthanasia by isoflurane overdose—are presented. A total of 4 SAR-OCT measurement parameters are reported in 6 longitudinal experiments: blood flow volume fraction, total retinal thickness, reflectance index, and scattering angle. As each mouse expires, blood flow volume fraction decreases, total retinal thickness increases, reflectance index decreases, and scattering angle diversity increases. Contribution of the retinal vasculature to scattering angle diversity is discussed. Results of this study suggest the utility of SAR-OCT to measure TE using scattering angle diversity contrast in the retina.
Databáze: Directory of Open Access Journals
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