Condition of pro-oxidant system in guinea pigs’ bronchi in experimental allergic alveolitis development and their correction with thiotriazolin

Autor: Mariana Ljubomurivna Baida, Mariana Muchailivna Fyrduchko-Regeda, Natalia Grugorivna Sementsiv
Jazyk: English<br />Spanish; Castilian<br />Polish<br />Russian<br />Ukrainian
Rok vydání: 2017
Předmět:
Zdroj: Journal of Education, Health and Sport, Vol 7, Iss 6, Pp 1066-1070 (2017)
Druh dokumentu: article
ISSN: 2391-8306
DOI: 10.5281/zenodo.1175286
Popis: Exogenic allergic alveolitis has been ascribed to multiple inhaled antigens found in a large variety of environmental settings. The immune mechanisms leading to this deases development are still incompletely understood. Initially, believed to be a classes III and IV immune response, we now have a clearer understanding of the complex inflammatory events involved. These include the release of pro inflammatory cytokines and a decrease in the immune control mechanisms via surfactant, dendritic and T-regulatory cells. Free radicals and reactive oxygen species could play a major role in the pathophysiology of allergic alveolitis . Despite the improved understanding, the treatment and outcome of this pathology have not known enough. This work determinate on accumulation of lipid peroxidaton products in the animals` bronchi during experimental allergic alveolitis and corrective effect of antioxidant-thiotriazolin on these indicators.
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