Surface protein imputation from single cell transcriptomes by deep neural networks

Autor: Zilu Zhou, Chengzhong Ye, Jingshu Wang, Nancy R. Zhang
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-020-14391-0
Popis: Cell-surface proteins serve as phenotypic cell markers and in many cases are more indicative of cellular function than the transcriptome. Here, the authors introduce a transfer learning framework to impute surface protein abundances from scRNA-seq data.
Databáze: Directory of Open Access Journals